The mission of the KwaZulu-Natal Office of the Premier is to support the Premier in carrying out his constitutional and statutory duties.

The Department fulfils this mission primarily by mobilising, coordinating and integrating the efforts of the provincial government and administration to eradicate various forms of human deprivation; playing a leadership role in mobilising and leveraging public and private sectors' resources to realise a sustainable economic growth, with the capacity to generate decent jobs and eradicate poverty and inequality; spearheading the efforts of provincial government and all stakeholders aimed at ensuring peace, safety and security for all; professionally executing departmental mandates; coordinating and facilitating macroprovincial and other transversal issues and programmes; promoting cooperative and good governance, including fighting against fraud and corruption; providing the highest quality of policy management, planning and monitoring, and evaluation services; creating policies relating to regulations, information and legislation; and supporting the executive branch of the provincial government in initiating and executing provincial laws and policies.